Global Abexinostat (Xynomic Pharmaceuticals) Market Overview 2017-2026: A Broad Histone Deacetylase (HDAC) Inhibitor
Dublin, June 26, 2019 (GLOBE NEWSWIRE) -- The "abexinostat" report has been added to ResearchAndMarkets.com's offering.
Abexinostat (Xynomic Pharmaceuticals) is a broad histone deacetylase (HDAC) inhibitor. HDAC enzymes (also known as lysine deacetylase) cleave acetyl groups from N-acetyl lysine amino acids on a histone. HDAC inhibition leads to highly acetylated histones and chromatin reshaping. In addition to altering histone acetylation, HDAC inhibitors can also influence the degree of acetylation on non-histone proteins, increasing or repressing their activity.
Through the epigenetic modulation of vascular endothelial growth factor expression, it is thought that abexinostat can prevent Votrient resistance. As such, the combination of abexinostat with Votrient (pazopanib; Novartis) is intended to prolong the therapeutic effect of Votrient. Therefore, we do not expect abexinostat to be investigated as a monotherapy for the treatment of renal cell carcinoma (RCC).
If approved, abexinostat will be the only HDAC inhibitor available for the treatment of RCC, and its novel mechanism of action within this market will place the drug in an advantageous position. Abexinostat is being developed for use in combination with the well-established therapy Votrient, and physician familiarity with this drug will facilitate the initial uptake of abexinostat.
However, based on the ongoing Phase III trial, abexinostat is only expected to launch for the US market, limiting its potential revenue. Additionally, the combination will face significant competition from other more established drugs and their generic counterparts, such as Inlyta (axitinib; Pfizer) and Afinitor (everolimus; Novartis).
Key Topics Covered:
OVERVIEW
- Drug Overview
- Product Profiles
- abexinostat : Renal cell carcinoma (RCC)
LIST OF FIGURES
- Abexinostat for RCC - SWOT analysis
- The authors drug assessment summary of abexinostat for RCC
- Abexinostat sales for RCC in the US, 2017-26
LIST OF TABLES
- Abexinostat drug profile
- Abexinostat Phase III data in RCC
- Abexinostat sales for RCC in the US ($m), 2017-26
For more information about this report visit https://www.researchandmarkets.com/r/adsh6i
Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.
CONTACT: ResearchAndMarkets.com Laura Wood, Senior Press Manager press@researchandmarkets.com For E.S.T Office Hours Call 1-917-300-0470 For U.S./CAN Toll Free Call 1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 Related Topics: Lymphoma Drugs
EIN Presswire does not exercise editorial control over third-party content provided, uploaded, published, or distributed by users of EIN Presswire. We are a distributor, not a publisher, of 3rd party content. Such content may contain the views, opinions, statements, offers, and other material of the respective users, suppliers, participants, or authors.