Amgen Wants a Seat at the Table With Its New Experimental Weight Loss Drug

The weight loss field has gained a new player as Amgen looks for a seat at the table alongside diabetes drugs from Eli Lilly and Co and Novo Nordisk

TENAFLY, NEW JERSEY, UNITED STATES, December 5, 2022 /EINPresswire.com/ -- The weight loss field has gained renewed medical and investor attention in recent months after diabetes drugs from Eli Lilly and Co and Novo Nordisk (NOVOb.CO), known as semaglutide and tirzepatide, were proven to help obese patients lose weight.

Both of those drugs, which need to be injected every two weeks, are designed to activate GLP-1, a hormone that triggers the feeling of fullness in the body after eating.

Amgen's AMG133 also targets GLP-1, but has a dual mechanism which aims at the same time to block activity of a gene known as GIP.

The drug was developed from work at Amgen to identify genetic signals associated with lower fat mass and body weight, and also healthy metabolic profiles, explained Saptarsi Haldar, head of cardiovascular metabolic discovery at Amgen.

"Genetics clearly showed in multiple large populations that decreased activity genetically of the GIP receptor gene was associated with lower BMI (body mass index)," he said.

The California-based biotech said it plans to launch a larger mid-stage study of AMG133 early next year, which will enroll a broader range of patients, including those with additional health conditions such as diabetes.

JP Morgan analyst Chris Schott earlier this month said that if all goes well, a Phase III study of AMG133 could begin in 2024, with a launch expected in 2026 or 2027, if approved.

Amgen Inc's experimental obesity drug demonstrated promising durability trends in an early trial, paving the way for a larger mid-stage study early next year, company officials said ahead of a data presentation on Saturday.

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